The pleiotropic benefits

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August undefined, 2024

WebbThe Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Beyond the Glycemic Benefit. Type 2 diabetes (T2D) is associated with an increased risk of macro- … Webb6 maj 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. 他汀类药物对血管炎症的作用可能是其具有多种功效的原因。而这一现象背后的分子过程尚未完全阐明。

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Webb1 jan. 2024 · The surprising pleiotropic effects that have led to improved cardiovascular morbidity and mortality will likely be the most impactful for this class of agents. Improvements in the structure and function of the myocardium validate the outcomes trials and shed some light on potential mechanisms of action. Author Disclosures WebbTo dissect the genetic basis of cotton breeding in China, a 16-parent cotton MAGIC population was newly developed in this study. 25 pleiotropic genomic loci were identified by GWASs, providing an explanation for the simultaneous changes between cotton yield and fiber quality. The narrow genetic structure of Chinese cotton cultivars was also … how do you break your pelvis

Investigating the Lowest Threshold of Vascular Benefits from LDL ...

Webb12 dec. 2011 · The pleiotropic alleles, their benefits and their pathophysiological costs are all briefly outlined. Our review of the research literature supports the hypothesis that at least some of the genetic factors that increase disease severity or risk may also confer certain reproductive or survival benefits, ... WebbOne of the most important pleiotropic effects of endorphins is regulation of the immune system, ... Thus, hippocampal dentate neural stem cells may be a potential benefit of endorphins in neuropathy associated with cranial neurogenesis disorders in adults, an important target. References. Gilbert DL, Horn PS, Kang PB, Mintz M, Joshii SM, ... WebbWhy you should supplement with pycnogenol: 7 health benefits. 1. Supports men's sexual health. Clinical research has shown that pine bark extract may provide significant sexual health benefits for men. Pycnogenol provides sexual health support by promoting endothelial nitric oxide synthase (eNOS), which is an enzyme that creates nitric oxide. how do you break your leg

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WebbABSTRACT. It has been proposed that the functions of the cyclin-dependent kinase inhibitors p21 Cip1/Waf1 and p27 Kip1 are limited to cell cycle control at the G 1 /S-phase transition and in the maintenance of cellular quiescence. To test the validity of this hypothesis, p21 was expressed in a diverse panel of cell lines, thus isolating the effects … Webb5 maj 2024 · In this review, we will present the cardiovascular and metabolic effects of GLP-1 agonists in type 2 diabetes, beyond serum glucose control. 2. Mechanism of action of GLP-1 hormone and its pleiotropic effects. Multiple organ dysfunction, with macrovascular and microvascular complications, represent an effect and also a … pho in little tokyoWebb13 juli 2024 · The current research and existing facts indicate that type 2 diabetes mellitus (T2DM) is characterized by gut microbiota dysbiosis and disturbed microbial metabolites. Oral glucose-lowering drugs are reported with pleiotropic beneficial effects, including not only a decrease in glucose level but also weight loss, antihypertension, anti … pho in longwood

"WebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... " - The pleiotropic benefits

The pleiotropic benefits

The Neurologist: Clinical & Therapeutics Journal - Benefits of ...

Webband immunity [2]. Thus, this Special Issue focuses on the pleiotropic beneﬁts of melatonin, ranging from the basic mechanisms of its cell interaction to its beneﬁcial effects under different disease conditions. Melatonin mainly mediates its effects through its MT1 and MT2 membrane recep- WebbLikewise, pleiotropic gene's stabilizing selection allows for the allele frequency to be altered. Studies on fungal evolutionary genomics have shown pleiotropic traits that simultaneously affect adaptation and …

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Webbevidence for the benefits of influenza immunization, par-ticularly in patients with recently diagnosed CV disease. Bruno Granwehr, MD University of Texas MD Anderson Cancer Center Houston, Texas, USA References 1. Centers for Disease Control and Prevention (CDC). Prevention and control of seasonal influenza with vaccines. Recommendations Webbför 10 timmar sedan · Astrocytes can exert pleiotropic and opposing effects on oligodendroglial survival and function, at least partly owing to their capacity to adopt a wide spectrum of reactive states, as reviewed in ...

Webb20 okt. 2024 · We have a QI [quality improvement] project going on from renal in which everyone is getting dose maxed out on an ACE or an ARB. They’re looking at it from some of the other pleiotropic effects. We also know they’re not dose-dependent CV benefits or renal benefits. That’s a great real-life use case regarding the most recent data from Dapa … Webb11 juli 2024 · The study of pleitropic genes is important to genetics as it helps us to understand how certain traits are linked in genetic diseases. Pleitropy can be spoken of …

WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM … Webb7 nov. 2011 · Many patients do not achieve their lipid targets on current treatment regimens, and discontinuing or modifying statin therapy based on lipid targets alone potentially ignores the potential valuable cardio- and vasculo-protective pleiotropic properties of these compounds and the benefits they may provide to patients in addition …

WebbPleiotropic cancer manifestations of germline CDH1 mutations: Risks and management ... [Anti-angiogenic therapies for metastatic colorectal, breast and lung cancer: benefits and risks]. Dorothea Wagner, K. Zaman, Yi …

Webb13 apr. 2024 · This study addresses the genetic bases underlying bilinguals’ language control ability to simultaneously juggle two or more languages, critically targeting that language control is shaped by inherent... pho in lincolnWebbVanderbilt University Medical Center. Mar 2007 - Jul 20147 years 5 months. Nashville, Tennessee, United States. TaqMan Genotyping, Sequenom MassArray, Sanger Sequencing, Illumina Infinium ... pho in los gatosWebb23 sep. 2010 · The pleiotropic properties of chlorthalidone were not appreciated before. and I think this study, although it's a basic science study, does confirm these special benefits chlorthalidone has beyond ... pho in londonWebbHowever, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering. Indeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function ... how do you break your kneeWebbCurcumin, being a pleiotropic molecule, is a regulator of multiple molecular targets which play crucial roles in various cell signaling pathways. It is known to suppress transformation, inhibit proliferation as well as induce apoptosis. However, despite all these benefits, the efficacy of curcumin remains limited due to its poor ... how do you break your sternumWebb12 apr. 2024 · Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been shown to improve cardiovascular and renal outcomes in patients with established cardiovascular disease, chronic kidney disease (CKD), and heart failure (HF) with reduced or preserved ejection fraction. Clinical benefit has been substantiated in patients with and without … how do you break your hipWebb27 aug. 2024 · The beneficial effect of empagliflozin on hepatic lipid metabolism and lipid accumulation independent of obesity, with the mechanisms understood to involve decreased lipogenesis, alterations in cytochrome P450 proteins, and decreased fetuin-A helping to alleviate NAFLD symptoms in the early phase of the disease and before the … pho in lowell